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The 30-second answer
Three recent reviews (2025 and 2026) of randomised trials found creatine raises blood creatinine by about 0.13 to 0.14 mg/dL, but with no significant change in the glomerular filtration rate (eGFR) or in the precise Cr-EDTA measure, so the authors read it as a change in creatinine metabolism, not kidney injury. A review of 63 studies (1,489 participants) found that with resistance training it increased strength (effect sizes 0.54 and 0.55) and lean mass (0.30) and raised body weight slightly (0.12). If you have kidney disease or take medicines that affect the kidneys, ask your doctor first.
Does creatine harm the kidneys? The latest three reviews
| Review | Sample | Result |
|---|---|---|
| de Souza 2026 (Int Urol Nephrol) | 26 studies, 1,036 participants (healthy people and chronic kidney disease) | Blood creatinine rose 0.14 mg/dL (0.05 to 0.22) and creatinine-based GFR fell 10.75 mL/min; but by Cr-EDTA it did not change (difference 5.89, −0.30 to 12.08), nor did urea or urine albumin. The authors: a change in creatinine metabolism, not kidney injury |
| Tsiaras 2026 (J Ren Nutr) | 19 randomised trials and a crossover study | Creatinine rose 0.13 mg/dL, with no difference in urea or eGFR (−5.20, −15.00 to 4.60). The authors asked for trials longer than a year |
| Naeini 2025 (BMC Nephrol) | 21 studies, 12 in the analysis (440 participants) | A small rise in creatinine (difference 0.07) and no significant difference in GFR; the authors: a small, transient rise from creatine turnover, with kidney function preserved |
- Kidney tests: if you have a creatinine test while taking creatine, tell your doctor and the lab, because it may come out higher than normal without kidney injury.
- If you have kidney disease or take medicines that affect the kidneys: ask your doctor first; the reviews say longer trials are needed.
- We do not say “100% safe”: the results are medium-term, and the latest review itself asked for longer studies.
What does it do, and does it add weight?
The 2026 Wang review in the Journal of the ISSN (63 studies, 1,489 participants) compared resistance training plus creatine with training alone. Creatine increased upper-body strength (effect size 0.54), lower-body strength (0.55), lean mass (0.30) and body weight (0.12), and lowered body-fat percentage slightly (−0.14), with no significant difference in fat mass. So the slight weight gain comes mainly from muscle, not fat, according to the authors. The effect on strength appears larger in younger people, but that is an exploratory analysis. And it is with training, not on its own.
Dose and best timing
The International Society of Sports Nutrition position stand (ISSN 2017) says supplementation short and long term (up to 30 g a day for 5 years) is safe and well tolerated in healthy people, and that habitually ingesting about 3 g a day from food across life is beneficial; the abstract does not give a usual supplement dose. The products we sell come in 5 g servings, so follow what is printed on your pack. On timing: a small 2026 trial in 11 men (a single dose of 0.1 g/kg) found that taking it before exercise raised performance more than during or after, but the authors called it exploratory and in need of a larger sample; so regularity matters more than the hour.
Creatine monohydrate at Beseha
These three are monohydrate according to their pages, and the full comparison with price per gram is in creatine monohydrate prices in Egypt 2026.
#1
100% monohydrateMicronized
Tractor Creatine Monohydrate – Micronized Powder
Creatine monohydrate powder with no flavours or additives
EGP 425
Current price from the product page
- The page: 100% micronized creatine monohydrate
- The page: dissolves quickly and mixes with water, juice or protein
- The page: free of flavours and additives
Heads-up: Follow the dose printed on the pack
#2
5 g per serving150 g and 300 g
Care Tech Creatine Monohydrate – 5 g per Serving
Creatine monohydrate in two sizes with the same serving
EGP 450
Current price from the product page
- The page: 5 g of creatine monohydrate per serving
- The page: 150 g and 300 g packs with the same serving
- The page: for resistance training and high-intensity activities
Heads-up: The price shown follows the size chosen on the product page
#3
Creapure®5 g per scoop
Nutri-Nations Creatine – 5 g Creapure®
Micronized creatine monohydrate sourced from Creapure®
EGP 950
Current price from the product page
- The page: 100% Creapure® as the creatine source
- The page: 5 g of creatine monohydrate per scoop
- The page: a single ingredient, no flavour or filler
Heads-up: The page states a purity of at least 99.9% for Creapure®, which is the page’s statement, not an independent test
Ask a doctor or pharmacist first if
- You have chronic kidney disease, are on dialysis or take medicines that affect the kidneys.
- You are pregnant or breastfeeding, or under 18.
- You have a chronic illness or take regular medicines.
- Pain, swelling, reduced urine or unusual symptoms appeared after you started: stop and ask.
Want to ask?
Beseha pharmacists answer on WhatsApp. Tap the “Ask a pharmacist” button and tell them your medicines and tests before you start.
FAQ
Does creatine harm the kidneys?
Three recent reviews (2025 and 2026) found a small rise in creatinine with no significant change in filtration (eGFR or Cr-EDTA), and explained it by creatinine metabolism. The latest review asked for longer studies, and if you have kidney disease ask your doctor.
Why does my creatinine test come out higher?
Because creatine is partly converted into creatinine; tell your doctor and the lab that you take creatine.
Does it add weight?
A review of 63 studies found a slight weight gain (effect size 0.12) coming mainly from muscle, not fat, with resistance training.
How many grams a day?
The studies we opened gave no single dose; the products we sell have a 5 g serving, so follow what is printed on the pack.
Before or after training?
A small trial (11 men) found better performance with the dose before training, but it is exploratory; regularity matters most.
Is it suitable for women?
The studies we opened analysed age and sex as factors and presented no confirmed different result for women; ask your doctor if you are pregnant or breastfeeding.
Read next: creatine monohydrate prices in Egypt 2026.
The bottom line
The latest reviews say creatine raises the creatinine test but with no significant change in kidney filtration, and increases strength and muscle with resistance training, with the slight weight gain coming from muscle. No single dose appears in what we opened, so follow the pack, tell your doctor and lab about kidney tests, and if you have kidney disease ask before you start.
Sources
- de Souza Almeida et al. 2026: creatine supplementation and kidney health, meta-analysis
- Tsiaras et al. 2026: creatine and kidney function, meta-analysis of randomised trials
- Naeini et al. 2025: creatine and kidney function, meta-analysis
- Wang et al. 2026: resistance training with creatine, three-level meta-analysis
- Ben Maaoui et al. 2026: timing of a creatine dose, pilot crossover trial
- Kreider et al. 2017: ISSN position stand on creatine safety and efficacy
- Tractor Creatine Monohydrate product page at Beseha
- Care Tech Creatine Monohydrate product page at Beseha
- Nutri-Nations Creatine product page at Beseha
This content is for information and is not a substitute for advice from a doctor or pharmacist. Prices and availability may change; the final price is on the product page.
